Abstract: [
Abstract ] Objective Toobservetheeffectofmultipleelectrolyticandinvertsugarinjection
onbloodglucose , insulin , C-peptide , baseexcess ( BE ), freefattyacidsinpatientsundergoing
operationofneurosurgery.Toevaluatetheeffectonenergymetabolisminpatientsandprovide
experienceforclinicalapplication.Methods Sixtypatients , ASA Ⅰ-Ⅱ , anesthetictimemore
than6hoursundergoingelectivecraniotomywererandomlydividedintothreegroups : invert sugar ( IS ) group , glucose ( GS ) group , normalsaline ( NS ) group ( n =20 ) .Thepatients'vitalsigns
weremonitoredsuchasnon-invasivebloodpressure , heartrate ( HR ), electrocardiogram , oxygen
saturation , thedepthofanesthesia ( BIS ) inoperatingroom.Afteropenningtheveinliquidpath ,
theanesthesia wasinduced.The patients underwent trachealintubation and mechanical
ventilation.Therightfemoralveinwaspunctured , anddorsalispedisarterypunctureofinvasive
arterialbloodpressurewasmonitored.Afterthecirculationstability , GS , IS , NSgroupswere
givensodiumchlorideandcextroseinjection500mL , 5% multipleelectrolyticandinvertsugar
injection500mLand500mLphysiologicalsalineinonehour , thennosugaryliquidwasgiven.
Bloodglucose , bloodinsulin , C-peptide , freefattyacidconcentrationsand BE value were
measuredatthetimeof0hour ( T 0 ) beforethecorrespondingfluidinfusion , infusionof250mL
( T
1 ), 0hourafterinfusion ( T 2 ), 1hoursafterinfusion ( T 3 ), 3hoursafterinfusion ( T 4 ) .Ifthe
measuredbloodglucoseconcentrationishigherthan10 mmol
/ LatT
3 , thenthatcasewillbe
excludedinthestudyandwillbetreatedwithinsulinformeasuringbloodglucose.Thepatients'
gender , age , weight , BMI , blood pressure , HR , BISimmediatelyatdrawing blood were
recorded.Bleedingandinfusion withliquidin operation wereamounted.Thenumberand
percentageofpatientswhogotadditionalinsulinwasamounted.Results Thebloodglucosewas
increasedfromT 0 , reachedthepeakatT 1 andwasdecreasedtoT 4 inthethreegroups.Butthe
increasedextentwasdifferent.Theinsulin , C-peptideinthethreegroupswereallincreasedand
thendecreased.ThepeakincreasedinISandGSgroupwasatT 2 , butintheNSgroupwasatT 1 ;
BEvaluesinISgroupandGSgroupweredecreasedgraduallyfromT 0 -T 3 andwereincreasedat
T 4 .In NSgroupBE values weredecreasedfrom T 0 -T 3 andincreasedatT 4 .There were
statisticallydifferencesinthebloodglucose , insulin , C-peptideandBE valuesinthethree
groups , thetimepoint , andtheinteractionofgroupsandtimepoints (
all P <0.01 ) .The
trendencyoffreefattyacidsinthethreegroupswerewithrisingandfallingtrendoffluctuations.
Buttherewerenostatisticallydifferencesinthethreegroups , thetimepoint , theinteractionof
groupsandtimepoints ( P >0.05 ) .Conclusion Infusionof5% multipleelectrolyticandinvert
sugarinjectionwillcausetheincreasmentinbloodglucose , insulin , C-peptidelevels , butitisin
clinicalallowedrange , whichwillbegoodtoprovideenergyforpatientwithelectivecraniotomy.

Key words: neurosurgicalprocedures , invertsugarinjection , energymetabolism