Abstract: [
Abstract ] Objective Todynamicallyobservecaspase-3andneuronspecificenolase ( NSE ) of
theneonatewiththedifferentstageofhypoxicischemicencephalopathyandtoexploretherelated
significance.Methods Sixty-seven ofchildren with hypoxicischemicencephalopathy were
randomlyselected , in which mild , moderateandseveregroup were23 , 23 , 21respectively.
Twentyneonatesoffulltermnormalwereascontrolgroup.Alltheneonatesin1day , 3days , 7
daysaftertheirbirthweretakenbloodtodetecttheserumlevelsofcaspase-3andNSE.Results
Caspase-3levelsineachgroupshowedatrendofincreaseinfirstdays , thirddaysandseventh
days , buttheamountoftheincreaseanddecreaseinthecontrolgroupwasverysmall , whilethe
changerangewasverybiginthemildHIEgroup , moderateHIEgroupandsevereHIEgroup ,
andtheheaviertheconditionthegreaterthefluctuation.ThelevelofNSEinthecontrolgroup
andthemildHIEgroupshowedatrendoffirstincreasingandthendecreasing.ButtheNSElevel
of moderate HIEgroupandsevere HIEgroupshowedagradualdownwardtrend.Thereis significantdifferencebetweenthegroups , thetimepointsandtheirinteraction ( P <0.01 ) .
Conclusion Bothcaspase-3andNSEwereinvolvedinthepathophysiologicalprocessofHIE , the
levelsofcaspase-3 and NSE werecloselyrelatedtotheseverity andthecourse of HIE
progression.The moreseverityofthe HIE , thehigherlevelofthetwoindicators.Dynamic
monitoringofthecaspase-3an

Key words: hypoxia-ischemia, brain ;
caspase3 , neuronspecificenolase