Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the effect of folic acid supplementation during pregnancy on the newborn infants with neural tube defects diseases.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Among 4 896 pregnant women who had been examined before marriage and were prepared for childbearing, a total of 1 416 pregnant women as the observation group were selected for gene testing, Using TaqmanMGB technology, genotype were performed in 5, 10methylenetetrahydrofolate reductase(MTHFR) A1298C and C677T gene loci and methionine synthase reductase(MTRR) A66G gene loci. According to the above gene function, homozygous, wild and frequency were analyzed. Ability to use folic acid gene detection was classified(normal, slightly poor, poor and very poor). Poor and very poor pregnant women were selected for individual oral folic acid supplementation and regular antenatal examination. A total of 1 416 pregnant women cases was defined as the control group, who did not receive folic acid by gene detection, only in accordance with the dose conventional oral folic acid 400 g/day and regular antenatal examination. Newborn neural tube defect disease(spina bifida and anencephaly, encephalocele, meningocele, incidence of cleft lip and palate) of 2 groups were recorded.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓①There was no significant difference in genotype and allele distribution in MTHFR two gene loci in the observation group and the Chinese population in the observation group(P＞005). There was significant difference in genotype and allele distribution in. MTRR gene loci in the observation group and the Chinese population in the observation group(P＜005). ②The ratio of folic acid utilization ability to detect gene was 72.46% in the observation group . ③The incidence rate of neural tube defects in pregnant women in the observation group was significantly lower than that of observation group(P＜005). 
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓More than half of the folic acid utilization ability of women of childbearing age in the sample area was collected, and different folic acid supplementation scheme could effectively reduce the incidence of neural tube defects.

Key words: neural tube defects, folic acid deficiency, neonate