Abstract: ［Abstract］  Objective〖HTSS〗〓To investigate the preventive effect of hemodialysis(HD) combined with hemoperfusion(HP) on atherosclerosis and cardiovascular complications in elderly patients with end stage renal disease(ERSD).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixty cases of elderly patients with ESRD treated by maintenance hemodialysis in our hospital were included and randomly divided into 2 groups, with 30 cases in each group, by random number table. The observation group was treated with HD+HP, while the control group was treated with sole HD. Fasting blood samples were collected before and 6 months after treatment, in order to detect and compare the level of apolipoprotein C3(ApoC3), high density lipoprotein(HDL),low density lipoprotein(LDL), triglyceride(TG), total cholesterol(TC), Creactive protein(CRP), hemoglobin(Hb）, albumin(ALB), interleukin6(IL6), interleukin8(IL8), tumor necrosis factorα(TNFα), carotid intimamedia thickness(CIMT)of patients were also detected. The incidence of cardiovascular complications were recorded.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓①6 months after treatment, IL6 and IL8 in the control group were significantly decreased (P＜005). While IL6, IL8, ApoC3, TG and CRP in the observation group were decreased significantly, HDL and ALB in the observation group were increased significantly(P＜005). The decreasing of IL6 and IL8 in the observation group were more obvious than in the control group, the differences were statistically significant(P＜005). ②6 months after treatment, CIMT in the control group was increased significantly(P＜005) compared with before treatment. While CIMT in the observation group did not change obviously. Nonconditional logistic regression analysis showed that APOC3, TG, IL6 and CRP were independent risk factors for CIMT thickening, and HDL was an independent protective factor for CIMT thickening(P＜005).③The incidence rate of myocardial injury and heart failure in the observation group were significantly lower than those in the control group, the differences were statistically significant (P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓HD+HP can inhibit the formation of atherosclerosis in elderly patients with end stage renal disease, which may be related to the inhibition of ApoC3, TG and CRP. This will help to reduce the incidence of various cardiovascular complications.

Key words: nephrosis； renal dialysis, perfusion, atherosclerosis, cardiovascular complications