Abstract: ［Abstract］  Objective〖HTSS〗〓To evaluate the clinical value of targeted prostate puncture guided by transrectal ultrasound(TRUS) and contrastenhanced ultrasound combined with MRI.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A retrospective analysis was performed in 187 patients who underwent prostate biopsy and confirmed by surgical pathology. One hundred and two patients had the transrectal ultrasoundguided systematic biopsy, and 85 patients had the targeted biopsy. The prostate cancer detection rate, needle number and Gleason score were compared between the 2 groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive rate and the coincidence rate of postoperative pathology of the target group were higher than that of the systematic group. The difference was statistically significant(P＜005), There was no significant difference in the detection rate of postoperative pathologic prostate cancer between the two groups(P＞005). Among the 85 cases of target puncture, 286pin in the highrisk group, 158pin in the dangerous group, 105pin in the suspicious group, and 63pin in the complement group. The positive rate of highrisk was higher than the suspicious group and the additional puncturing group, the difference was statistically significant(P＜005). The coincidence rate of high score of the Gleason score in the target group was higher than that in the systematic group, the difference was statistically significant(P＜005). There was no statistically significant difference in Gleason score of postoperative pathologic findings between two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓TRUS and contrastenhanced ultrasound combined with MRI compartmental localization can significantly improve the positive rate of prostate cancer, reduce the number of puncture needles, and improve the detection rate of high Gleason score of prostate cancer, which have a higher clinical value.

Key words: prostate cancers, transrectal ultrasound, contrastenhanced ultrasound;　magnetic resonance imaging, targeted prostate biopsy