Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze the effect of Lcarnitine on heart function, blood connective tissue, growth factor (CTGF) and Nterminal probrain natriuretic peptide (NTProBNP) of patients with end stage renal disease and dialysis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 124 cases of maintenance hemodialysis patients were selected. All patients were divided into control group and observation group with 62 cases in each group. The patients in the control group were treated with hemodialysis. The patients in the observation group were treated with Lcarnitine for chemotherapy. The cardiac function, CTGF and NTProBNP levels in the two groups were analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Compared with pretreatment group, the hematocrit(Hct) and haemoglobin(Hb) of the two groups were improved, the difference was statistically significant（P＜005）. Compared with the control group, the Hct and Hb of the observation group were improved significantly after treatment, the difference was statistically significant （P＜005）. Compared with pretreatment group, left ventricular ejection fraction(LVEF), cardiac output(CO), cardiac index(CI) and stroke volume(SV) of control group and observation group were significantly improved, and the difference was statistically significant (P＜005). Compared with the control group, the LVEF, CO, CI, SV, heather index（HI） and left ventricular mass index(LVMI) of the observation group were significantly improved after treatment, the difference was statistically significant (P＜005). Compared with the control group, the levels of CTGF and NTProBNP in the observation group and the control group were significantly lower than those in the control group (P＜005), and the difference was statistically significant. The levels of CTGF and NTProBNP were significantly lower in the treatment group (P＜005), and the difference was statistically significant.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓 Lcarnitine can improve the anemia and cardiac function of patients with endstage renal disease and hemodialysis, and reduce the levels of CTGF and NTProBNP, promote the repair of damaged cardiac muscle cells and restoring myocardial contractility of patients. It can provide reference for clinical treatment.

Key words: nephrosis； Lcarnitine, cardiac function, connective tissue growth factor