Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze the immunophenotype of myeloma cells in patients with multiple myeloma (MM) and its relationship with clinical stage, immunoglobulin typing and prognosis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A retrospective analysis of newly diagnosed adult MM patients, which were admitted to department of hematology in our hospital, and statistical analysis of the clinical characteristics of myeloma cell immunophenotype and MM typing, staging, age and prognosis etc were performed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓①The positive rate of CD56 expression in MM patients with different immunoglobulin types was different(P＜0.05), IgG 47.42%, IgA 25.77%, light chain type 18.56%, IgD 8.25%. ②The positive rates of CD38, CD138, CD19, CD20 and CD117 in the immunophenotype of myeloma cells were not significantly different between different stages, different age groups and different M protein types(P＞005). ③The 3 year OS rate and 3 year EFS rate of CD56+MM were 60.7% and 45.1%, respectively, and both were higher than CD56-MM(25.2%, 15.2%, P＜005). The 3 years OS rate of CD56+MM in the over 60 years group was 60.9%, higher than CD56-MM (20.0%) (P＜0.05). The 3 years OS rate of Ⅲ stage of was 48.3%, higher than CD56-MM(18.3%) (P＜0.05). ④The 3 years OS rate and 3 years EFS rate of CD117+MM were 65.2% and 44.4%, respectively, and both were higher than CD117-MM(25.3%, 10.6%)(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓①In some MM patients, tumor cells show B cell antigen expression, but not in the entire sample. ②As for the positive rate of CD56 expression, the IgG type was the highest; the clinical stage and the different age had little effect on the positive rate of the immunophenotype of myeloma cells. ③CD56+ has a good prognosis, especially for elderly patients or MM with higher clinical stage, and CD56+ is a better prognostic indicator. ④The survival rate of CD117+ patients is high, and the prognosis is good.

Key words: multiple myeloma, immunophenotyping； prognosis