Abstract: ［Abstract］ Objective〖HTSS〗〓To observe the effects of early stage in gestational diabetes mellitus on expression levels of Nesfatin1 , interleukin6(IL6), tumor necrosis factorα(TNFα) and adiponectin(APN).
 〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Followup method have been used in this trail,all the subjects were chosen from pregnant women who accepted health care in our hospital, a total of 103 cases, which means all the subjects were pregnant for 24 weeks,and at this moment, 75 grams of glucose tolerance screening tests were applied to them, abnormality has been examined .The normal control group was selected from the volunteers who had no abnormalities during the same period, 56 cases were included. The general conditions of the 2 groups(including age, height, weight, pregnancy test time), serum Nesfatin1 and APN, IL6, TNFα inflammatory factors in the early pregnancy were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There was no significant difference in the age, height, weight, pregnancy examination time and other signs between the experiment group and the control group(P＞0.05). The levels of serum Nesfatin1 and IL6 and TNFα in the experimental group were higher than those in the control group at the early stage of pregnancy, while APN was lower than that in the control group, the differences were statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The detection of inflammatory factors such as serum Nesfatin1 and APN, IL6 and TNFα levels in early pregnancy can play an early role in predicting gestational diabetes mellitus. Early intervention on gestational diabetes mellitus can reduce the incidence of maternal and infant complications.

Key words: diabetes, gestational； adiponectin； interleukin6； , tumor necrosis factoralpha