Abstract: ［Abstract］〓Objective〖HTSS〗〓To assess the value of Xpert MTB/RIF in the early diagnosis and drug resistance of suspected spinal tuberculosis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Appling the Xpert MTB/RIF system to detect pus specimens from 168 suspected spinal tuberculosis surgery. Taking clinical diagnosis as the gold standard，the sensitivity and specificity of Xpert MTB/RIF for detection of Mycobacterium tuberculosis were calculated, and the differences in sensitivity and specificity between acidfast staining and rapid culture of Mycobacterium tuberculosis were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓In the pus specimens of 168 patients with spinal tuberculosis, 134 cases of Xpert MTB/RIF were positive for Mycobacterium tuberculosis, of which 25 cases were resistant to rifampicin.Clinical diagnosis as the gold standard，the sensitivity of Xpert MTB/RIF for detecting Mycobacterium tuberculosis was 79.76%(134/168) and the specificity was 96.87%(47/50).There were 25 rifampicinresistant mutant genes in 134 cases of spinal tuberculous pus, and the drugresistant mutation rate was 18.66%. In the pus specimens of 168 patients with spinal tuberculosis, 51 cases were positive for acidfast staining  and 70 cases were positive for rapid culture of Mycobacterium tuberculosis.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Xpert MTB/RIF is a molecular detection technique that can simultaneously detect mycobacterium tuberculosis and rifampicin resistance in spinal tuberculosis.It has high diagnostic value in the rapid diagnosis of spinal tuberculosis.

Key words: tuberculosis, spinal； diagnosis； resistance