Abstract: ［Abstract］〓Objective〖HTSS〗〓To observe the effects of the recombinant human brain natriuretic peptide (rhBNP) on the postoperative brain natriuretic peptide (BNP), cardiac troponin I(cTnI) and left ventricular ejection fraction (LVEF) of the offpump coronary artery bypass grafting(OPCABG).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 103 cases of OPCABG in our hospital were randomly divided into the rhBNP and the control group, including 52 of the rhBNP group and 51 in the control group. Before operation, immediately after operation(before medicinal), 24 h after operation, 48 h after operation,and 7 days after operation, the blood was extracted to detect the BNP and the cTnI and cardiac color doppler uhrasonography was examined to check up LVEF.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The difference between the two groups patients of saphenous bypass graft was statistically significant(P＞005). cTnI and the BNP of the two groups were increased first and then decreased, and the peak value of cTnI was at 24 h after the operation. The peak value of BNP was at 48 h after operation, and the variation of rhBNP group was less than that of the control group. The LVEF of 2 groups showed a trend of decreasing first and then increasing. The lowest value was at 48 h after operation, and the rhBNP group was higher than that of the control group. There was significant difference in interaction between group, time point and group point(P<0.05). There was no statistically significant difference in cardiovascular events between the two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The OPCABG postoperative application of rhBNP can reduce the release of endogenous BNP and cTnI. RhBNP can be used to improve postoperative cardiac function.

Key words: natriuretic peptide, brain, coronary artery bypass grafting, cardiac troponin