Abstract: ［Abstract］ Objective〖HTSS〗To observe the clinical efficacy of losartan potassium tablets combined with Bailing capsules in the treatment of chronic kidney disease.
〖HTH〗〖WTHZ〗Methods〖HTSS〗160 patients with nephropathy were randomly divided into four groups: control group, losartan group, Bailing capsule group and combined drug group. The control group was given symptomatic treatment by controlling diet, controlling blood pressure and maintaining water, electrolyte and acid-base balance; the losartan group was given losartan potassium tablets 50 mg/time, once a day; the Bailing capsule group was given Bailing capsules 2.0 g/time, three times a day; the combined drug group was given losartan and Bailing capsules at the same time. The treatment lasted 6 months. Serum creatinine(SCr), blood urea nitrogen(BUN), 24 hour urinary protein quantification and inflammatory factor levels of leukotropin-1(Lknactin-1) and vascular endothelial growth factor(vascular endothelial growth factor) were measured before and after treatment. Vascular growth factor, high sensitive C-reactive protein(hs-CRP), tumor necrosis factor-α(TNF-α) and interleukin-18(IL-18) were detected.
〖HTH〗〖WTHZ〗Results〖HTSS〗The overall efficacy of losartan group, Bailing capsule group and combined drug group was higher than that of control group, and the overall clinical efficacy of combined drug group was higher than that of Bailing capsule group and losartan group, with statistical significance(P＜0.05); renal function index of combined drug group was compared with that of single Bailing capsule and losartan group, after treatment, SCr, BUN After treatment, the levels of serum inflammatory factors Lkn-1, VEGF, hs-CRP, TNF-alpha and IL-18 were significantly higher in the combined group than those in the single Bailing capsule group and losartan group(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗The combination of losartan potassium tablet and Bailing capsule can reduce urinary protein, BUN and SCr content, improve renal function, relieve glomerulosclerosis, effectively delay renal fibrosis, effectively improve renal function index and inflammatory factor level.

Key words: kidneyfailure, chronic, glomerulonephritis, losartan potassium, Bailing capsules