Abstract: ［Abstract］ Objective〖HTSS〗〓To evaluate the safety and efficacy of drug coated balloon(DCB) in the treatment of arteriosclerosis obliterans of lower extremities.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 94 cases of lower extremity arteriosclerosis obliterans were randomly divided into 2 groups, 46 cases in the control group treated with conventional balloon dilatation plus stenting, 48 cases in the treatment group expanded by Medtronic Inc DCB balloon, and stent plasty was given when necessary. The patients were followed up for 6 months and 12 months after the operation to compare the late vascular lumen loss in the 2 groups. The late lumen loss, restenosis rate, revascularization rate and incidence of malignant events were compared between the 2 groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After 6 months of followup, the loss of advanced vascular lumen in the treatment group was less than that of the control group. The difference was statistically significant(P＜005), and there was no significant difference in the restenosis rate, revascularization rate and the incidence of malignant events between the 2 groups(P＞005). After 12 months of followup, the loss of advanced vascular lumen in the treatment group was less than that of the control group. The restenosis rate of the treatment group was less than that of the control group, the difference was statistically significant(P＜005), but the revascularization rate and the incidence of malignant events in the 2 groups were not statistically significant(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓DCB balloon has a good longterm effect in the treatment of arteriosclerotic occlusive disease of the lower extremities. It can obviously reduce the loss of vascular lumen and restenosis rate at 12 months after operation.

Key words: arterial occlusive diseases, drugeluting stents, angioplasty, balloon