Abstract: ［Abstract］ Objective〖HTSS〗〓To determine the relationship between insulinlike growth factor1（IGF1） mRNA levels of bone tissues and the pathogenesis of type 2 diabetic osteoporosis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓After fed with high fat diet for 8 weeks, rats was injected with streptozotocin intraperitoneally and had ovariectomy to establish type 2 diabetic osteoporosis rat mode. The body weight, fasting plasma glucose, insulin and bone mineral density were analyzed in type 2 diabetic osteoporosis rats. Realtime PCR was used to measure the expression of IGF1 in bone tissue of type 2 diabetic osteoporosis rats.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Twelve weeks after ovariectomy, body weight of normal ovariectomy(NOVX) group was slightly higher than that of normal control（NC） group. Body weight of diabetic control（DC） group and diabetic ovariectomy（DOVX） group was lower than that of NC group and NOVX group. And body weight of DOVX group was higher than that of DC group(P＜005). The level of fasting blood glucose of NOVX group was lower than that of NC group. The levels of fasting blood glucose of DC group and DOVX group were higher than those of NC group and NOVX group. And the level of fasting blood glucose of DOVX group was higher than that of DC group(P＜005). The levels of fasting insulin were increased gradually and insulin sensitivity was decreased gradually in all groups(P＜005). Bone mineral density of NOVX group was lower than that of NC group. Bone mineral density of DC group was lower than that of NC group and was higher than that of NOVX group(P＜005). The relative levels of IGF mRNA were decreased gradually among groups(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The level of IGF1 mRNA in rat bone tissue decreased with the decrease of bone mineral density.

Key words: osteoporosis； bone mineral density, insulinlike growth factor Ⅰ