Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the correlation between serum levels of carcinoembryonic antigen(CEA), carbohydrate antigen 125, carbohydrate antigen 199 and alphafetoprotein(AFP) in patients with gastric cancer and the depth of invasion of gastric cancer, and to evaluate the clinical value of endoscopic submucosal dissection(ESD) in patients with gastric cancer.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The serum levels of carcinoembryonic antigen, carbohydrate antigen 125, carbohydrate antigen 199 and AFP in 107 patients with gastric cancer before operation were detected by electrochemiluminescent immunoassay. The value of each index in judging the depth of invasion of gastric cancer was retrospectively analyzed by using the working characteristic curve and the area under the curve.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of serum tumor markers CEA, carbohydrate antigen 125, carbohydrate antigen 199 AFP in group B were significantly higher than those in group A(P＜0.05). The accuracy of combined detection of serum tumor markers CEA, carbohydrate antigen 125 and carbohydrate antigen 199 in predicting the feasibility of ESD treatment in patients with gastric cancer was 75.70%.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Combined detection of serum tumor markers CEA, carbohydrate antigen 125 and carbohydrate antigen 199 has a high sensitivity for predicting the depth of invasion of gastric cancer patients, and has a certain reference value for judging whether ESD treatment is feasible for such patients.

Key words: stomach neoplasms； carcinoembryonic antigen, endoscopic submucosal dissection