Abstract: 〖WTHZ〗［Abstract］〓Objective〖HTSS〗〓To investigate the efficacy and safety of mechanical thrombolysis with intravenous and intraarterial thrombolysis in patinets with acute intracranial large artery occlusion.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The clinical data of 38 patients with acute intracranial large artery occlusion by using the combined mechanical thrombolysis with intravenous and intraarterial thrombolysis were analyzed retrospectively. There were 9 cases in internal carotid artery,18 cases in middle cerebral artery,11 cases in basilar artery .The clinical effects and safety were analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓According to the stroke type and vascular condition, mechanical thrombolysis was used in 3 patiens. Arterial thrombolysis was used in 13 patients. Mechanical thrombectomy was used in 23 patients. Balloon dilatation was used in 3 patients. Stenting was used in 5 patients. Occluded large arteries of  33 patients were dredged totally or partialy，the recanalization rate or partial recanalization rate of blocked blood vessel was 86.8%,including 22 cases with total recanalization(57.9%),11 cases with partial recanalization(28.9%). The target blood flow evaluated by modified thrombolysis in cerebral infarction can reached form 2b-3 grade. After operation four cases suffered from cerebralhemorrhage，including 1 case of frontal lobe hemorrhage, 1 case of basal ganglia and temporal lobe hemorrhage,6 cases died． 32 patients were survived from treatment. Over time,the ranks of National Institute of Health Stroke Scale gradually decreased, the ranks of Activity of Daily Living Scale gradually increased, and the difference was statistically significant(P＜0.05). The degree of modified Rankin Scale showed no significant difference between leaving and 6 months after departure from the hospital(P＞0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Mechanical thrombolysis with intravenous and intraarterial thrombolysis in patinets with acute intracranial large artery occlusion is a safe and an effective therapy within 4.5 h intravenous thrombolysis time window．

Key words: brain ischemia； mechanical thrombectomy, intraarterrial thrombolysis, intravenous thrombolysis