Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze the changes of nuclear factor kappa B(NFκB), neuronspecific enolase(NSE) and lactic acid levels in peripheral blood and the prognostic value of these indicators in children with fevered convulsion.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 100 cases of children with fevered convulsion were selected as subjects. According to the time and frequency of onset, they were divided into simple group(SFS group) 58 cases and complex group(CFS group) 42 cases, and 50 cases without fevered convulsion in the same period were selected as the control group. The expression levels of transcription factor NFκB and NSE were detected by elisa. All indexes were followed up for 6 months, and the prognosis of the children was predicted by ROC curve analysis.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of serum NFκB, NSE, lactic acid and blood glucose in the SFS group and CFS group were higher than those in the control group(P＜005). The levels of NFκB, NSE, lactic acid and blood glucose were all higher than those of < 2 times. The levels of NFκB, NSE, lactic acid and blood glucose were all higher than those of ＜15 min(P＜005). The frequency and duration of convulsion were positively correlated with NFκB, NSE level, lactic acid and blood glucose. According to the ROC curve analysis, the area under the curve of NSE, NFκB and lactic acid for the prognosis of children with convulsion was 0.819, 0.778 and 0.709, respectively, while the area under the ROC curve of the three combined was 0.838. During the 6month followup, 20 cases(47.6%) of the patients with complicated fevered convulsion relapsed, and 10 cases(23.8%) were converted to epilepsy. The incidence rate was higher than that of 12 cases(20.7%) and 3 cases(5.2%) of the patients with simple fevered convulsion relapsed, and the difference between the two groups was statistically significant(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The levels of NSE, NFκB, lactic acid and blood glucose in peripheral blood of children with feverinduced convulsion were all increased, and increased with the frequency and duration of convulsion. The combined detection of NFκB, NSE and lactic acid was of great significance for the prognosis of children with feverinduced convulsion and was worthy of clinical application.

Key words: seizures, febrile, nuclear factor kappa B, neuronspecific enolase