Abstract: ［Abstract］Objective〖HTSS〗To explore the feasibility of quantitative CT in evaluating the effect of anti-osteoporosis treatment.
Methods〖HTSS〗The patients with postmenopausal osteoporosis were treated with bisphosphonate. Serum β-C-terminal collagen of type Ⅰ collagen(β-CTX), dual energy X-ray bone density and quantitative CT bone density were measured before and 6 months after treatment. According to the change of serum β-CTX, the patients were divided into two groups: the effective group and the ineffective group.
Results〖HTSS〗A total of 220 patients were included. 211 patients whose serum β-CTX content decreased by more than 50% were regarded as the treatment effective group， 9 patients whose serum β-CTX content decreased less than 50% were regarded as the treatment ineffective group. After 6 months of oral bisphosphonates treatment, there was no significant change in dualeneopausal X-ray absorptiomtry bone mineral density(BMD) in the effective group and the ineffective group. Quantitative CT BMD in the effective group indicated that BMD increased, but there was no significant change in the ineffective group.
Conclusion〖HTSS〗The detection of serum β-CTX and quantitative CT BMD can evaluate the effect of anti bone resorption in postmenopausal osteoporosis patients, and the two detection methods are complementary to each other, providing guidance for the treatment of postmenopausal osteoporosis.

Key words: osteoporosis； &beta, -C-terminal telopeptide of type Ⅰ collagen； cone-beam computed tomography