Abstract: Objective  To explore the effect of bone transfer combined with joint bone grafting and internal fixation in the treatment of large bone defects of the lower extremities and the serum basic fibroblast growth factor(bFGF) and platelet-derived growth factor platelet derived growth factor(PDGF), vascular endothelial growth factor(VEGF), transforming growth factor β(TGF-β) expression. 
Methods  Fifty patients with large-segment bone defects of the lower limbs were selected for surgical treatment, and they were divided into a single group(25 cases) and a combined group(25 cases) using a random number table method. The single group was treated with bone transfer, and the combined group was treated with contralateral bone grafting and internal fixation on the basis of the single group. Comparing the healing status, complication rate, and serum inflammatory factors ［C-reactive protein(CRP) and tumor necrosis factor-α(TNF-α) and nuclear factor kappa-B(NF-κB)］, bFGF, PDGF, VEGF, TGF-β, immediately after contact with the opposite ends and 1 week after contact between the two groups expression. 
Results  The complication rate of bone healing index, bone healing time, external fixation time, nonunion of bone commissure, and nail infection was significantly lower than that of the single group. The excellent rate of bone healing was significantly higher than that of the single group(P＜0.05); Immediately after exposure to the end, the levels of CRP, TNF-α, NF-κB and bFGF, PDGF, VEGF, TGF-β were not significantly different(P＞0.05), 1 week after exposure, combined group CRP, the levels of TNF-α and NF-κB were significantly lower than those of the single group, and the levels of bFGF, PDGF, VEGF and TGF-β were significantly higher than those of the single group(P＜0.05). 
Conclusion  Bone transfer combined with end-to-end bone grafting for the treatment of large segmental bone defects can effectively shorten the bone healing time, improve the bone healing, reduce the inflammatory response and increase the level of bone regeneration related factors, and reduce the patients. Complications have clinical significance.

Key words: fracture fixation, bone transfer, fracutre healing