Abstract: Objective  To observe the clinical efficacy of  clostridium butyricum tablets combine with ferrous succinate tablets treatment on iron deficiency anemia and the incidence of anemia complications. 
Methods  Eighty-one children with iron deficiency anemia were selected and randomly divided into treatment group(40 cases) and control group(41 cases). The control group was given ferrous succinate tablets, and the treatment group was treated with clostridium butyricum tablets combined with ferrous succinate tablets. Hematocrit, hemoglobin, serum iron and serum ferritin anemia were compared between two groups, and the adverse reactions of nausea, vomiting, anorexia, diarrhea and constipation were compared between two groups, and the clinical efficacy was compared between two groups. 
Results  After treatment, hematocrit, hemoglobin, serum iron and serum ferritin levels of the two groups were higher than those before treatment, hematocrit, hemoglobin, serum iron and ferritin levels in the treatment group were higher than those in the control group, the difference was statistically significant(P＜0.05). The incidence of adverse reactions in the treatment group was lower than that in the control group(P＜0.05). There was no significant difference in the total effective rate between two groups(P＞0.05). 
Conclusion  The efficacy of clostridium butyricum tablets combined with ferrous succinate tablets in the treatment of iron deficiency anemia is better than that of ferrous succinate tablets monotherapy. It can significantly reduce the incidence of adverse reactions and has good clinical use value. 

Key words: anemia, iron-deficiency； clostridium , butyricum； ferrous succinate； child