Abstract: ［Abstract］Objective〖HTSS〗To study effects of the human recombinant epidermal cell growth factor, recombinant human epidermal cell length factor(rhEGF) combined with skin and soft tissue expander on TLR4 level and type Ⅰ collagen Ⅲ ratio in patients with facial and neck scar plastic surgery.
〖WTHZ〗Methods〖HTSS〗A total of 108 patients with facial and neck scar were selected and divided into observation group and control group, according to the random number table method. The control group was treated with skin and soft tissue dilatation, while the observation group was treated with rhEGF and skin and soft tissue dilatation. Compare the immediate retraction rate, skin expansion ratio, expansion time, collagen type Ⅰ/Ⅲ ratio, hydroxyproline(hydroxyprolin, OHP) content, Toll-like receptor 4(Toll-like receptor4, TLR4) expression level, clinical efficacy, adverse events of 2 groups of patients.
〖WTHZ〗Results〖HTSS〗 In the observation group, immediate retraction rate, expansion of completion time, collagen type Ⅰ/Ⅲ ratio were significantly lower than those of the control group, and skin expansion rate and OHP of the observation group were significantly higher than those of control group(P＜0.01). The repair effect of the observation group was better than that of the control group, and the total effective rate was higher than that of the control group(P＜0.01).
〖WTHZ〗Conclusion〖HTSS〗RhEGF combined with skin and soft tissue expander has a good effect in the treatment of facial and neck scar, with low incidence of adverse reactions and good safety.

Key words: cicatrix； surgery, plastic； epidermal growth factor； tissue expansion