Journal of Hebei Medical University ›› 2021, Vol. 42 ›› Issue (2): 201-204.doi: 10.3969/j.issn.1007-3205.2021.02.017

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Efficacy and safety of ultra pulse CO2 fractional laser combined with recombinant bovine epidermal growth factor gel in the treatment of facial depressed scar after surgery

  

  1. 1.Department of Dermatology, Zhengding Branch of the 980th Hospital of the Joint Logistics Support 
    Force of Chinese People′s Liberation Army, Hebei Province, Zhengding 050800, China; 2.Department of 
    Plastic Surgery， Yanjiao People′s Hospital of Sanhe City, Hebei Province, 
    Sanhe 065200, China
  • Online:2021-02-25 Published:2021-03-09

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Abstract: Objective  To investigate the efficacy and safety of ultra pulse CO2 fractional laser combined with recombinant bovine basic epidermal growth factor gel in the treatment of facial depressed scar after surgery. 
Methods  A total of 100 patients with depressed facial scar after surgery were selected and divided into observation group and control group according to patient number. The control group was treated with ultra pulse CO2 fractional laser once every 2 months, for a total of 5 times as 1 course of treatment, and the observation group was supplemented with recombinant bovine basic epidermal growth factor gel on the basis of the control group. After each laser treatment, recombinant bovine basic fibroblast growth factor gel was applied twice a day for 20 d. After one course of treatment, the curative effect, duration of wound scab formation, erythema duration, duration of wound pain, skin dryness and tension, patient satisfaction and adverse reactions such as infection, edema and new scar were compared between two groups. 
Results  There was no significant difference in the total effective rate between  two groups(P＞0.05). Duration of wound scab formation, erythema and wound pain was shorter in the observation group than in the control group, and the incidence of skin dryness and tension was lower than that of the control group; the patient satisfaction was higher than that of the control group, and the total incidence of adverse reactions during treatment was lower than that of the control group, suggesting significant difference(P＜0.05). 
Conclusion  The combination of ultra pulse CO2 fractional laser and recombinant bovine basic epidermal growth factor gel in the treatment of depressed facial scar after surgery failed to improve the curative effect, which, however, could accelerate wound repair, relieve wound pain and discomfort such as skin dryness and tension, improve patient satisfaction and reduce the incidence of adverse reactions during treatment. 


Key words: scar, lasers, gas, recombinant bovine basic epidermal growth factor gel