Abstract: Objective  To investigate the effect of aerobic exercise on peripheral blood T and B lymphocyte subsets，pulmonary circulation and systemic circulation of patients with chronic obstructive pulmonary disease(COPD) at stable stage. 
Methods  A total of 98 patients with COPD at stable stage treated were selected as the research subjects, and they were randomly divided into control group（routine intervention group） and observation group（routine intervention and aerobic exercise group）, with 49 cases in each group. Then the peripheral blood T lymphocyte subsets（CD3+， CD4+ and CD8+） and B lymphocyte subsets（CD19+， CD5+ and CD20+）， pulmonary circulation indexes（mean pulmonary arterial pressure and pulmonary vascular resistance） and systemic circulation indexes（mean systemic arterial pressure and peripheral vascular resistance） of two groups at different time points before and after the intervention were compared. 
Results  The peripheral blood T lymphocyte subsets，peripheral blood B lymphocyte subset，pulmonary circulation indexes and systemic circulation indexes SVR of observation group at 6 and 12 weeks after the intervention were all significantly better than those of control group，and there were statistically significant differences（P＜0.05）. 
Conclusion  The effect of aerobic exercise on peripheral blood T and B lymphocyte subsets，pulmonary circulation and systemic circulation of patients with COPD at stable stage is relatively better，and it has a higher application value in the patients with COPD at stable stage. 

Key words: pulmonary disease, chronic obstructive, T-lymphocyte subsets, B-lymphocyte subsets