Abstract: Objective  To explore the predictive value of intrapapillary capillary loop(IPCL) typing combined with Cyclin D1 and platelet-derived growth factor receptor(PDGFR) in the diagnosis and prognosis of esophageal cancer. 
Methods  A total of 118 patients with superficial esophageal lesions(118 lesions) examined by NBI-ME were enrolled in this study.The esophageal cancer tissues were classified based on IPCL typing and pathological typing, and Cyclin D1 and PDGFR expression in esophageal cancer tissues were detected. They were followed-up for 5 years after operation, and patient survival was recorded. 
Results  Based on ICT typing of esophageal cancer with superficial esophageal lesions, type Ⅲ and type Ⅳ were mainly esophagitis and LGIN. Type V1, type V2 and type V3A were mainly early esophageal cancer(EEC), and the sensitivity, specificity, positive predictive value(PPV) and negative predictive value(NPV)in the diagnosis of EEC were 85.5%(71/83), 80.0%(28/35), 91.0%(71/78), and 83.9%(28/40), respectively. Type V3B and type VN were mainly SM1, SM2, and lower segment esophageal cancer. The sensitivity, specificity, PPV and NPV in the diagnosis of SM2 and lower segment esophageal cancer were 70.0%(7/10), 92.6%(100/108), 46.7%(7/15) and 90.7%(100/103), respectively. The expression of Cyclin D1 and PDGFR in patients with EEC, SM1, SM2 and lower segment esophageal cancer was significantly higher than that in patients with esophagitis and LGIN(P＜0.01). The 5-year survival rate of EEC patients with strong positive expression of Cyclin D1(P=0.036) and PDGFR(P=0.034) was significantly lower than that of patients with positive, weak positive or weak negative expression. IPCL typing, expression of Cyclin D1 and PDGFR in EEC were independent risk factors for the prognosis of EEC. 
Conclusion  IPCL typing has certain guiding significance for the diagnosis of EEC. Detection of Cyclin D1 and PDGFR expression in esophageal cancer tissues is conductive to the prognosis of EEC. IPCL typing, and expression of Cyclin D1 and PDGFR are the independent risk factors for the prognosis of EEC.

Key words: esophageal neoplasms, intrapapillary capillary loop, diagnosis