Abstract: Objective  To study the vaccination willingness and influencing factors of human papillomavirus(HPV) for college students in Shijiazhuang City by using different models to analyze different knowledge scores, and to provide the theoretical basis for the promotion of HPV vaccine for college students in Shijiazhuang City. 
Methods  Using a random sampling method, a questionnaire on demography, HPV and cervical cancer cognition, sexual behavior, HPV vaccine cognition and vaccination intention was conducted universities in Shijiazhuang City, and a total of 1622 valid questionnaires were retrieved. The Chi-square test was used to analyze the differences in basic information, sexual behavior and infection consciousness of college students with different vaccination intentions. The Mann-Whitney U test was employed to observe the effect of HPV-related knowledge on vaccination intention in those students, and the Logistic regression model was used to analyze the factors affecting vaccination. 
Results  45.62%(740/1622) of college students expressed their willingness to receive HPV vaccine, while 54.38%(882/1622) expressed their unwillingness. The total scores for HPV-related issues were 6.000（2.000，10.000） and 1.000（-2.000，5.250） for students in the willingness and unwillingness groups respectively, with statistically significant differences(P＜0.001), The total score was divided into HPV score and cervical cancer-related knowledge score as well as HPV vaccine-related knowledge score, and the difference was still statistically significant（P＜0.001). The results of Logistic regression analysis showed that HPV-related knowledge score was statistically associated with vaccination willingness(P＜0.001); the higher the score, the higher the intention to vaccinate. After adjusting living expenses, gender, origin and other factors, OR value was decreased in models 1, 2, and 3; after taking sexual behavior and infection risk consciousness into consideration, OR value was increased in model 4, as compared with model 3. 
Conclusion  The acceptance rate of HPV vaccination for college students in Shijiazhuang City is lower than that at the national level. Therefore, improving HPV-related knowledge of college students will increase their acceptance rate of vaccines, and the relevant departments still need to strengthen publicity and efforts to enhance the awareness of self-protection of college students. 

Key words: papillomavirus vaccines, influencing factor analysis, college students