Abstract:

Objective To analyze the effect of continuous positive pressure ventilation(CPPV) on blood glucose and serum macrophage migration inhibitory factor(MIF) in the treatment of obstructive sleep apnea hypopnea syndrome(OSAHS) patients with diabetes. 
Methods Clinical data of 68 patients with OSAHS and diabetes were collected. All patients were treated with CPPV. At 3 months after consecutive treatment, the improvement of fasting blood glucose (FBG) and the levels of inflammatory factors including serum MIF were observed to discuss the feasibility of CPPV. 
Results At 3 months after treatment, the total effective rate of OSAHS patients with diabetes was 95.59%(65/68). Compared with that before treatment, the apnea-hypopnea index(AHI) of patients decreased significantly after treatment, and the lowest arterial oxygen saturation(LSpO2) increased significantly(both P＜0.05). Compared with those before treatment, the levels of glucose metabolism indexes, and the levels of inflammatory factors including serum MIF significantly decreased after treatment(all P＜0.05). MIF was positively correlated with AHI and FBG(r=0.501, 0.457, both P＜0.05), and negatively correlated with LSpO2(r=-0.423, P＜0.05). 
Conclusion CPPV has favorable curative effect in the treatment of patients with OSAHS and diabetes, which can significantly improve the inflammatory factors and glucose metabolism indicators of the patients.

Key words: sleep apnea, obstructive, diabetes mellitus, continuous positive pressure ventilation