Journal of Hebei Medical University ›› 2022, Vol. 43 ›› Issue (3): 280-285.doi: 10.3969/j.issn.1007-3205.2022.03.007

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Meta-analysis of the correlation between gene polymorphism of vitamin D receptor and metabolic syndrome

  

  1. 1.Grade 2020, the Graduate School of Hebei Medical University, Hebei Province, Shijiazhuang 050017，

    China; 2.Institute of Chronic Non-communicable Disease Prevention and Control, Hebei Provincial

    Center for Disease Control and Prevention, Hebei Province, Shijiazhuang 050024，China;

    3.Department of Epidemiology and Statistics, College of Public Health, North China University of Science and Technology, Hebei Province, Tangshan 063210， China

  • Online:2022-03-25 Published:2022-04-14

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Abstract:

Objective To explore the relationship between the gene polymorphism of vitamin D receptor(VDR) and genetic susceptibility to metabolic syndrome(MetS).

Methods Pubmed, CNKI, Wanfang and Chinese Biomedical Literature Database were searched to obtain the related articles about the relationship between FokI rs2228570 G＞A, BsmI rs1544410 G＞A polymorphism and MetS susceptibility up to March 2021. Stata12.0 statistical software was used for meta-analysis. Combined odds ratio(OR) and its 95% confidence interval(95%CI) were used to evaluate the correlation strength.

Results A total of 9 articles with 4 239 subjects were included. The results of meta-analysis showed that the FokI rs2228570 polymorphism could significantly increase the genetic susceptibility to MetS; in allele model(f vs. F), dominant model(ff+Ff vs. FF), recessive model(ff vs. Ff+FF) and homozygous model(ff vs. FF), the OR and 95%CI were 1.25(1.07-1.46), 1.25(1.09-1.44), 1.40(1.10-1.77) and 1.51(1.13-1.03), respectively. The BsmI rs1544410 polymorphism could significantly decline the genetic susceptibility to MetS; in allele model(b vs. B) and heterozygous model(Bb vs. BB), the OR and 95%CI were 0.86(0.76-0.98) and 0.77(0.62-0.95), respectively.

Conclusion VDR gene polymorphism is significantly related to genetic susceptibility to MetS. FokI f allele may be a risk factor for MetS, and BsmI b allele may be a protective factor for MetS.

Key words: metabolic syndrome, receptors, calcitriol, meta-analysis