Abstract:

Objective To compare the perioperative analgesic effect and safety of single multi-point thoracic paravertebral nerve block and continuous thoracic paravertebral nerve block during unilateral thoracotomy.

Methods A total of 84 lung cancer patients who underwent unilateral thoracotomy in our hospital were randomly divided into single group(single multi-point thoracic paravertebral nerve block) and continuous group(continuous thoracic paravertebral nerve block), with 42 cases in each group. The dosage of anesthetic during operation, extubation time, length of post-anesthesia care unit(PACU) stay, postoperative pain at different time points, times of analgesia pump pressing, times of rescue analgesic use and occurrence of adverse reactions were compared between two groups.

Results There was no significant difference in dosage of sufentanil, propofol and sevoflurane, extubation time, length of PACU stay, times of postoperative analgesia pump pressing, times of rescue analgesic use and total incidence of adverse reactions between two groups(P＞0.05). There was a statistically significant difference in the time effect and interaction effect of the visual analogue scale(VAS) score during cough and at resting between two groups(P＜0.001), and there was no statistically significant difference in the effect between groups(P＞0.05). The VAS pain score during coughing in both groups was higher than that at resting(P＜0.05). There was no significant difference in the VAS scores at resting and during cough between the continuous group and the single group at 1 h, 6 h, 12 h, 24 h, and 48 h after surgery(P＞0.05).

Conclusion The perioperative analgesic effect of single multi-point and continuous thoracic paravertebral nerve block during unilateral thoracotomy is similar, and the incidence of adverse reactions of the latter is lower.

Key words: nerve block, lung neoplasms, analgesia