Journal of Hebei Medical University ›› 2022, Vol. 43 ›› Issue (5): 570-573,582.doi: 10.3969/j.issn.1007-3205.2022.05.014

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Expression of GDF15 and TK1 in serum of patients with ovarian cancer and Cox regression analysis of prognosis

  

  1. 1.Department of Gynecology and Reproductive Endocrinology， Women and Children′s Medical Center of

    Guangzhou City, Guangdong Province, Guangzhou 510000, China; 2.Department of Medical Imaging, Heze Hospital of Traditional Chinese Medicine， Shandong Province, Heze 274000, China

  • Online:2022-05-25 Published:2022-05-30

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Abstract:

Objective  To explore the expression of recombinant growth differentiation factor 15(GDF15) and thymidine kinase 1(TKI) in the serum of patients with ovarian cancer and their correlation with prognostic Cox regression.

Methods  Prospect selection was performed on 50 healthy physical examinees(control group), 52 patients with ovarian benign disease(benign group), and 51 patients with ovarian cancer(ovarian cancer group) who underwent serum testing. Serum GDF15 and TK1 were tested, and the expression levels of GDF15 and TK1 in the three groups were compared. In the meantime, patients with ovarian cancer were followed up for 2 years, and they were divided into two groups according to survival or death of patients, namely survival group(n=41) and death group(n=10). The clinicopathological characteristics of the two groups were compared, and their crelationship with survival status was analyzed by Cox regression model.

Results  The serum GDF15 expression (816.65±88.46) ng/L and the TK1 expression level (1.46±0.65) pmol/L of the ovarian cancer group were higher than those of the benign group and the control group (P＜0.05). According to ROC curve analysis, the AUC of GDF15, TK1 and the combination of the two in predicting ovarian cancer was 0.879, 0.813, and 0.884, respectively. Patients with ovarian cancer were followed up for 2 years. The follow-up survival time of the survival group was (22.56±1.15) months, which was longer than that ［(14.16±2.65) months］ of the death group, and the difference was statistically significant (t=15.473, P＜0.001). The Cox regression model showed that the regression coefficient values of TK1 and GDF15 were -2.208 and -1.687 respectively, and the RR values were 0.110 and 0.185 respectively. Both had a negative impact on survival time. The regression coefficient value of FIGO staging was 3.059, which had a positive impact on survival time.

Conclusion  Serum GDF15 and TK1 levels are highly expressed in patients with ovarian cancer, and are closely related to the occurrence, development and prognosis of ovarian cancer, which have certain guiding significance for prognostic prediction.

Key words: ovarian neoplasms, growth differentiation factor 15, thymidine kinase