Abstract: Objective To investigate the relationship of soluble cluster of differentiation antigen 14 (sCD14), angiopoietin 2 (Ang2), and C-reactive protein (CRP) with the prognosis of emergency traumatic fracture patients with multiple injuries and their significance. 
Methods A total of 324 patients with traumatic fractures and multiple injuries were selected and divided into the good outcome group (n=275) and the poor outcome group (n=49) according to their disease outcomes at the time of discharge. The general data and the levels of sCD14, Ang2, and CRP were compared between two groups. The relationship between sCD14, Ang2, and CRP and the injury severity score (ISS) was analyzed by Pearson analysis. Cox regression analysis was used to analyze the relevant factors affecting the prognosis of patients with emergency traumatic fracture and multiple injuries. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of sCD14, Ang2 and CRP for disease outcome. 
Results The ISS score of the poor outcome group was higher than that of the good outcome group (P＜0.05). The sCD14, Ang2 and CRP in the poor outcome group were higher than those in the good outcome group (P＜0.05). sCD14 (r=0.785), Ang2 (r=0.778), and CRP (r=0.842) were positively correlated with ISS score (P＜0.05), and sCD14, Ang2 and CRP were all independent risk factors related to prognosis (P＜0.05). The area under ROC (AUC) of sCD14, Ang2, and CRP for predicting disease outcome was 0.813, 0.757, and 0.749, respectively. The two indicators with the highest predictive sensitivity (sCD14) and the highest specificity (Ang2) were selected for ROC analysis of the combination of sCD14+Ang2, showing that the AUC of the two combined in predicting disease outcome was 0.935, which was greater than any single index (P＜0.05). 
Conclusion sCD14, Ang2 and CRP are related to the severity and prognosis of emergency traumatic fracture patients with multiple injuries, and can be used as markers for predicting the prognosis of the disease. However, the combined detection of sCD14 and Ang2 can improve the prediction reliability and provide more accurate reference information for clinical diagnosis and treatment.

Key words: fractures, multiple, trauma and injuries, soluble cluster of differentiation antigen 14