Abstract: Objective To observe the effect of recombinant human acidic fibroblast growth factor (rhaFGF) combined with fusidic acid cream on wound healing, inflammatory level and pain mediators in patients with deep second degree burn. 
Methods A total of 120 patients with deep second degree burn treated in hospital were selected as the research subjects and divided into observation group (n=40), control group one (n=40) and control group two (n=40) according to random number table method. Control group one was treated with escharectomy combined with rhaFGF, control group two was treated with escharectomy combined with fusidic acid cream, and the observation group was treated with escharectomy combined with rhaFGF and fusidic acid cream. Patients in the three groups were treated continuously until wound healing. The levels of interleukin-2 (IL-2), interferon-γ (IFN-γ), interleukin-10 (IL-10), interleukin-6 (IL-6), 5-hydroxytryptamine (5-HT) , prostaglandin E2 (PGE2) and neuropeptide Y (NPY) were measured before and after treatment in the three groups. The granulation growth of the three groups was evaluated on the 5th, 10th, 15th and 20th day of treatment, and the wound healing time of the two groups was recorded. The wound healing rate on the 10th day, on the 15th day, and on the 20th day, and the average time of wound healing were recorded. After wound healing, the degree of scar hyperplasia in the three groups was evaluated by Vancouver Scar Scale (VSS), and the adverse reactions in the three groups were recorded. 
Results The levels of IFN-γ and IL-6 in observation group were lower than those in control group one and control group two (P＜0.05), the levels of IL-2 and IL-10 in observation group were higher than those in control group one and control group two (P＜0.05), and the levels of PGE2, 5-HT and NPY in observation group were lower than those in control group one and control group two (P＜0.05). There were significant differences of interaction between time points, groups and time points between groups with respect to granulation growth scores (P＜0.05), and the difference of interaction between groups, time points and time points between groups were statistically significant with respect to wound healing rates (P＜0.05). The mean wound healing time and scar hyperplasia score of observation group were lower than those of control group one and control group two (P＜0.05), and there were no obvious adverse reactions in the three groups. 
Conclusion rhaFGF combined with fusidic acid cream in the treatment of deep second degree burn patients can improve the levels of IL-2 and IL-10, reduce the levels of IFN-γ, IL-6, PGE22, 5-HT and NPY, inhibit inflammation, reduce pain mediators, promote granulation and healing, and reduce scar hyperplasia, with high safety. 

Key words: burns, fibroblast growth factors, fusidic acid cream