Abstract: Objective To construct and validate a risk early warning model for retinal vein occlusion (RVO) in patients with primary hypertension. 
 Methods From January 2021 to December 2022, 32 patients with concurrent RVO were screened out from 1 046 patients with primary hypertension admitted to the Second People′s Hospital of Kashgar Prefecture, and they were designated as the RVO group. Another 50 patients were randomly selected from the remaining patients as the control group. The RVO patients were divided into a high central retinal thickness (CRT) group (n=10) and a low CRT group (n=22) according to whether the CRT of the macular center was greater than 369 μm. The general data between the RVO group and the control group were compared. The levels of blood platelet count (BPC) and mean platelet volume (MPV) in plasma were compared between the high CRT group and the low CRT group. The influencing factors of RVO complicated with primary hypertension were analyzed. According to the results of Logistic regression analysis, a risk early warning model for RVO complicated with primary hypertension was constructed, and a nomogram was drawn. Using RVO complicated with primary hypertension as the positive sample, a receiver operating characteristic (ROC) curve was established, and the goodness of fit of this risk early warning model was verified by Hosmer-Lemeshow test. 
 Results The levels of BPC ［(271.31±31.42)×109/L］ and MPV ［(9.52±0.88) fL］ in the RVO group were higher than those in the control group ［(256.38±28.45)×109/L, (7.85±0.73) fL, P＜0.05］. The levels of BPC ［(288.31±34.42)×109/L］ and MPV ［(10.84±0.82) fL］ in the high CRT group were higher than those in the low CRT group ［(262.38±24.45)×109/L, (8.59±0.65) fL, P＜0.05］. The results of multivariate Logistic regression analysis showed that BPC and MPV were the influencing factors of RVO complicated with primary hypertension (P＜0.05). The ROC curve indicated that the area under the curve (AUC) value of the combined prediction of BPC and MPV (AUC=0.928, 95%CI: 0.876-0.981) was significantly better than the individual predictions of BPC (AUC=0.740, 95%CI: 0.629-0.851) and MPV (AUC=0.919, 95%CI: 0.862-0.976). And the goodness of fit of this risk model was verified to be good by Hosmer-Lemeshow test. 
 Conclusion BPC and MPV are significantly correlated with RVO complicated with primary hypertension and the severity of RVO, and the constructed risk model has a good fit. 

Key words: primary hypertension, retinal vein occlusion, blood platelet count, mean platelet volume