Abstract: Objective To explore whether wild-type p53-induced phosphatase 1 (Wip1 ) relates with poor prognosis of patients with glioma.Methods The expression of Wip1 in the brain tissue was examined using immunohistochemistry method in different grades of primary glioma(81 cases)and normal brain tissues(15 cases).Analysis was made on the relationships between Wip1-positive patients and various clinicopathological characteristics including the gender,age,glioma pathological grade,tumor size,location,PCNA expression,p53 expression and Karnofsky performance status(KPS)score at the time of surgery.For survival analysis,we used the Kaplan-Meier method.Results The expression of Wip1 in glioma samples was higher than that of normal brain tissues 55.6%(45/81)vs 0.0%(0/15)(χ2 = 15.686,P <0.01).The survival rate of the glioma patients with positive Wip1 expression was significantly lower than that of the glioma patients with negative Wip1 expression.Wip1 was associated with the glioma pathological grade.The Wip1 expression was positive correlated with PCNA expression,Lower KPS score, Wip1 positive expression and higher pathology classification were risks for poor prognosis of glioma patients.Conclusion Wip1 overexpression in brain glioma tissues was significantly associated with poor survival of glioma patients.

Key words: glioma, protein phosphatase 1, prognosis