Abstract: Objective  To explore the value of platelet aggregation rate and platelet adhesion rate in evaluating the condition and prognosis of children with sepsis. 
Methods  A total of 118 children with sepsis were selected as the research subjects. The basic data and biochemical indicators that might affect the short-term prognosis of all children were collected. All children were followed up for 28 days after admission to evaluate their survival.The risk factors affecting the short-term prognosis of children with sepsis were analyzed. The platelet aggregation rate and platelet adhesion rate of children with different severities of sepsis were analyzed. The value of platelet aggregation rate and platelet adhesion rate in predicting the short-term prognosis of children with sepsis was analyzed. 
Results  Of 118 children with sepsis, 20 died and 98 survived during the follow-up period. Pediatric logistic organ dysfunction-2 (PELOD-2) scores, oxygenation index, thrombin time (TT), and lactic acid were higher in the death group than in the survival group, while pediatric critical illness score (PCIS), platelet aggregation rate, and platelet adhesion rate were lower than those in survival group (P＜0.05). Multivariate Logistic regression analysis showed that PELOD-2 score, lactic acid score, PCIS score, platelet aggregation rate and platelet adhesion rate were risk factors affecting the prognosis of children with sepsis (P＜0.05). Among the 118 children with sepsis, 69 had no septic shock and 49 had septic shock. The platelet aggregation rate and platelet adhesion rate in septic shock group were higher than those in non-septic shock group (P＜0.05).The results of receiver operating characteristic (ROC) curve showed that the sensitivity of platelet aggregation rate, platelet adhesion rate and their combination to predict the short-term prognosis of children with sepsis were 75.00%, 70.00% and 80.00%, respectively, the specificity was 74.49%, 80.61%, 88.78%, respectively, and the area under the ROC curve was 0.761, 0.768, 0.913, respectively. 
Conclusion  The combination of platelet aggregation rate and platelet adhesion rate is effective in predicting the short-term prognosis of children with sepsis. 

Key words: sepsis, platelet aggregation rate, platelet adhesion rate, prognosis