Journal of Hebei Medical University

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Effect of enteral nutrition with -3 fatty acid on the response to C-reactive protein and nutritional metabolism in severe neurosurgical patients

  

  1. 1.Graduate School, Chengde Medical College, Hebei Province,Chengde 067000, China; 2.Department of 
    NeurosurgeryⅠ, the Hebei General Hospital, Shijiazhuang 050051, China
  • Online:2016-07-25 Published:2016-08-11

Abstract: [
Abstract ] Objective Toobservetheeffectsofenteralnutritionω-3fattyacidonreducing
thelevelofC-reactiveproteinandimprovingnutritional metabolisminsevereneurosurgical
patients.Methods The patients who had severe neurosurgery disease were dividedinto
experimentalgroupandcontrolgroupbypaireddesignmethod.Eachgroupwasconsistedof20
patients.Theexperimentalgroupistreatedwithω-3fattyacidsenteralnutrition , thecontrol
groupistreatedwithtraditionalenteralnutrition.Beforetreatmentandaftertreatmentatday1 ,
day4 , day7 , day14 , C-reactiveprotein , albumin , prealbuminandtransferrinlevels were
measuredin2groups.Results Afternutritionaltherapy , thelevelofC-reactiveproteinintwo
groupswererisingfirstthengoingdownlater.Thelevelinexperimentalgroupwaslowerthan
thatincontrolgroup.Thelevelofalbumininexperimentalgroupwasgoingdownfirstandrising
slowlylater , thelevelincontrolgroupwasgoingdownandneverrisingagainin2weeks , andthe
levelinexperimentalwashigherthanlevelincontrolgroupafter1week , Thereweresignificant
differencesintheinteractionofthetimepointsbetweenthetwogroups , thegroups , andthe
groupsvstimepoints ( P <0.05 ) .Thelevelofprealbuminandtransferrinwerelowerthanthat
beforenutritionaltherapy , thelevelinexperimentalgroupwashigherthanthatincontrolgroup inthefirst4daysoftreatment.Thereweresignificantdifferencesinthetimepointsandgroups
(
P <0.05 ) .Therewerenotsignificantdifferencesintheinteractionofthetimepointsvstime
points ( P >0.05 ) .Conclusion ω-3Fattyacidsenteralnutritioncanobviouslyreducethelevelof
C-reactiveproteinandimprovenutritionalmetabolisminsevereneurosurgicalpatients , which
wassuperiortogeneralnutritioninimprovingthenutritionalstatusandalleviatingthenegative
nitrogenbalance.

Key words: craniocerebraltrauma , fattyacids, omega-3 , C-reactiveprotein , nutritional metabolism