Abstract: ［Abstract］  Objective〖HTSS〗〓To evaluate the relationship between the uptake of fluorodeoxyglucose（FDG） and the expression of vascular endothelial growth factor（VEGF） as well as  p53 in breast cancer with lymph node metastasis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The selected 92 cases with breast cancer had been  performed positron emission computed tomography before operation,and recorded the maximal standard uptake value. The expression of VEGF or p53 of breast cancer tissue were tested after operation, and the positive expression rates of VEGF or p53were calculated. The relationship were analyzed between the uptake of FDG and the expression of VEGF and p53 in breast cancer with lymph node metastasis.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive expression rates of p53 and VEGF with lymph node metastasis were obviously higher than that without lymph node metastasis in breast cancer(P<0.05). The expression of VEGF was correlated with the expression of p53 in breast cancer tissue with lymph node metastasis(rs=0.563, P=0.000). The expression of VEGF was correlated with the expression of p53 in breast cancer tissue with no lymph node metastasis(rs=0.430, P=0.000). When the positive expression of VEGF or p53 became stronger, the SUVmax values was increased gradually(P<0.05). The SUVmax value showed positive correlation with the expression of VEGF or p53 in breast cancer tissue(rs=0.730, P=0.019, rs=0.610, P=0.035).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The  expressions of VEGF and p53 are associated with lymph node metastasis of breast cancer, and the SUVmax values are related to the expressions intensity of VEGF and p53. Maybe there is a synergistic effect between VEGF and p53. And the uptake of FDG maybe reflect the ability of lymph node metastasis and tumor invasion. It provides the basis for further clinical guidance for rational treatment.

Key words: breast neoplasms, deoxyglucose, vascular endothelial growth factors