Abstract: 〗［Abstract］ Objective〖HTSS〗〓To examine the effects of  local mild hypothermia therapy on patients with acute cerebral infarction and to further investigate underlying mechanism for the treatment of cerebral infarction.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred cases of cerebral infarction patients were randomly divided into two groups with 50 patients in each group. The control group was given standard medical treatment. The treatment group was given standard medical treatment plus mild hypothermia with a target temperature of 33 ℃ to 35 ℃. Hypothermia was maintained for 24 hours. MRI cerebral infarction volume was observed at the first day and the fifth days after admission. Modified Rankin scale(mRS) scores were measured at 3 months after infarction. The serum levels of superoxide dismutase(SOD) and malondialdehyde(MDA) were assessed before（on admission）and after mild hypothermia therapy(at 72 h after infarction).
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There was no difference in infarct volume between the two groups(P＞005). The concentration of SOD was higher in treatment groups than in control group(P＜005) at 72 h after infarction. The concentration of MDA was lower in treatment groups than in control group(P＜005) at 72 h after infarction. Patients in the treatment group with good prognosis(mRS<3 scores) were higher than those in the control group, the difference was statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Mild hypothermia treatment can improve the prognosis of patients with cerebral infarction, the beneficial effects may be accomplished by reducing oxidative stress reaction.

Key words: brain infarction, hypothermia, prognosis