Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the correlation of serum levels of secreted frizzledrelated protein 5(sFRP5) and Nterminal Btype natriuretic peptide(NTProBNP) with chronic heart failure(CHF).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and three CHF patients with New York Heart Association(NYHA) grade Ⅱ-Ⅳ and 44 healthy controls treated were summarized. The sFRP5, NTProBNP, fasting blood glucose，total cholesterol, triacylglycerol, low density lipoprotein cholesterol were detected，the height, weight, body mass index, blood pressure were taken and left ventricular ejection fraction(LVEF) and left ventricular enddiastolic dimension(LVEDD) were measured by echocardiography.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of sFRP5 and NTproBNP were significantly increased compared with the control group, the levels of sFRP5, NTproBNP and LVEDD were gradually increased whereas the LVEF was decreased with NYHA classification(P<0.05). sFRP5 and NTproBNP levels were positively correlated with NYHA grade and LVEDD respectively, and negatively correlated with LVEF(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓sFRP5 and NTproBNP are associated with the severity of cardiac function, and the combined application of them could be effective indexes for evaluating early diagnosis of chronic heart failure.

Key words: heart failure, natriuretic peptide, brain, secreted frizzledrelated protein 5