Abstract: ［Abstract］ ObjectiveTo analyze the distribution of pathogenic bacteria in pulmonary infection and related influencing factors in patients with critical heart failure.
〖WTHZ〗MethodsEighty patients with critical heart failure treated were divided into infection group(n=39) and uninfected group(n=41) according to whether or not pulmonary infection occurred. The clinical baseline data of the two groups were compared, and the influencing factors and independent risk factors of pulmonary infection were analyzed by univariate and multivariate Logistic regression analysis. The sputum samples of the infected group were collected and the distribution of pathogenic bacteria was analyzed and recorded.
〖WTHZ〗ResultsSingle factor analysis showed that age, smoking, diabetes, hypertension, chronic obstructive pulmonary disease, antibiotic or hormone abuse, left ventricular ejection fraction(left ventricular ejection fractions,LVEF)<35%, LVEF 35%-54%, longer hospital stay and higher expression of C-reactive protein（CRP） were the influencing factors of infection in patients, and the difference was statistically significant(P＜0.05 or P＜0.01). Multivariate logistic regression analysis showed smoking, diabetes, chronic obstructive pulmonary disease and antibiotics  or hormone abuse, LVEF<35%, and higher expression of CRP were among the independent risk factors leading to infection in patients, with a statistically significant difference(P＜0.05). A total of 42 pathogens were detected in 39 patients, including 28 Gram-negative bacteria(66.67%),11 Gram-positive bacteria(26.19%) and 3 fungal strains(7.14%).
〖WTHZ〗ConclusionThe main pathogens of pulmonary infection in patients with critical heart failure are gram-negative bacteria, followed by gram-positive bacteria, with relatively few fungi, smoking, history of diabetes, history of chronic obstructive pulmonary disease, abuse of antibiotics or hormones, LVEF<35%, and high expression of CRP are independent risk factors leading to infection.

Key words: heart failure, pneumonia, distribution of pathogenic bacteria, influencing factors