Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze the effect of calcipotriol combined with halometasone on treating psoriasis and the influence on skin barrier function and serum leptin.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Ninetysix  patients with psoriasis were selected as the research object, all of them were randomly divided into observation group and control group, each group with 48 cases. The observation group was treated with calcipotriol combined with halometasone by sequential method, while control group was treated with calcipotriol only. The clinical effect, skin barrier function, serum leptin and chrelin before and after 6 week treatment were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The total effective rate of observation group was 81.25%, which was significantly higher than that of the control group 54.17%(P＜005). Before treatment, there was no different of sebum content, moisture content in stratum corneum and skin moisture loss between two groups, after treatment, the sebum content and moisture content of two groups were raised, the skin moisture loss were reduced significantly(P＜005). And the sebum content and moisture content of observation group were higher than control group(P＜005). The skin moisture loss was lower than control group significantly(P＜005). Before treatment, the serum leptin and ghrelin were not significantly different, the two targets of both group were reduced after treatment, and the observation group was significantly lower than control group(P＜005). The adverse reaction rate of observation group was significantly lower than control group(P<005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Calcipotriol combined with halometasone can effectively increase the effect on treating psoriasis, improve the skin barrier function, decrease serum leptin and ghrelin levels, decrease adverse reaction rate, which has a good effect on the treatment of psoriasis.

Key words: psoriasis, calcipotriol, halometasone, leptin