Journal of Hebei Medical University

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Effects of early intensive antihypertensive therapy joint programmed sedative analgesia treatment on elderly patients with hypertension cerebral hemorrhage hematoma size and NIHSS#br#

  

  1. 1.Department of Neurosurgery, Handan Steel & Iron Group Staff Hospital, Hebei Province, Handan
    056001, China; 2.Department of Neurosurgery, the Second Hospital of Hebei Medical University,
    Shijiazhuang, 050000, China; 3.Neuroscience Research Center, Hebei Medical
    University, Shijiazhuang 050017, China
  • Online:2018-07-25 Published:2018-07-04

Abstract: [Abstract] Objective〖HTSS〗〓To explore the effect of early intensification pressure control strategy combined with sedative analgesia strategy on hematoma change and neurological function score in elderly patients with hypertensive cerebral hemorrhage.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixty nonsurgical treatment patients with hypertensive intracerebral hemorrhage were randomly divided into 2 groups and 30 patients in each group. The control group was given a routine depressurization program to control systolic blood pressure < 160 mmHg. The observation group was given earlycontrolled pressure combined, and 120-140 mmHg systolic blood pressure. The hematoma volume and the NIHSS scores at 0 d, 1 d and 14 d in two groups were surveyed, and the rates of hematoma enlargement were evaluated.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The hematoma volume and the NIHSS scores of 2 groups were both increased a little at 1 d treatment, and decreased significantly at 14 d treatment, which more reduction was detected in observation group. The differences between intergroup, time point, and interaction of intergroup and time point of 2 groups all had the statistical significances(P<005), but there were no statistical significances in hematoma enlargement rates between two groups(P>005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Early pressure control combined with sedative analgesia can effectively control the increase of hematoma. This therapeutic scheme is beneficial for the hematoma clearance and neurological function improvement.

Key words: intracranial hemorrhage, hypertensive; early enhancement of hypotension, sedation and analgesia