Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze the distribution characteristics and drug resistance of pathogens in patients with bloodstream infection from Baoding NO.1 Hospital, and to provide reference for selecting effective antibiotics to treat infection.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Blood culture results from Baoding NO.1 Hospital on 2014-2016 were analyzed, the isolated pathogens were collected using VITEK2 Compact automatic microbial analysis system for bacteria identification and antimicrobial susecptibility test, and the results were analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓A total of 698 strains were isolated from 5 020 blood samples, the positive rate was 13.90%, including 417 strains of gramnegative bacillus, accounted for 59.74%, with Escherichia coli and Klebsiella pneumonia, and 221 strains of grampositive coccus, accounted for 31.66% of coagulase negative staphylococci. Higher blood culture positive rate was followed by digestive medicine, urology and ICU. Escherichia coli and Klebsiella pneumoniae showed relatively low resistants to piperacillin/tazobactam, cefotetan, Amikacin, imipenem and meropenem.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Escherichia coli and Klebsiella pneumoniae of gramnegative bacillus are the main pathogenic bacteria in patients with bloodstream infection from Baoding NO.1 Hospital. Coagulase negative staphylococcus separation rate is higher, clinicians should pay attention to blood culture specimens and bacterial drug resistance monitoring, and to use antibiotics rationally for delaying the generation of drugresistant strains.

Key words: bacterial infections, blood culture, drug resistance rate