Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the relationship between level of serum 25hydroxyvitamin D［25(OH)D］ and ankle bone marrow edema syndrome.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓We made a retrospective analysis of clinical date of ninety three patients who were diagnosed with BMES in ankle joint. Pearson′s linear correlation analysis and multiple linear regression analysis were used to analyze the relationship between serum 25(OH)D levels and American Orthopedic Foot and Ankle Society(AOFAS) scores, Visual Analogue Scale(VAS) scores, age, sex and number of affected bones.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓In all 93 patients, the serum levels of 25(OH)D ranged from 17.69 to 57.07nmol/l with an average serum 25(OH)D levels of (32.6±11.8) nmol/l, and 83.9%(78/93) of patients had low vitamin D levels with serum levels of 25(OH)D below 50 nmol/l, 61.3%(57/93) of patients were vitamin D deficient, 22.6%(21/93)of patients were vitamin D insufficient, and only 16.1%(15/93) patients had sufficient vitamin D levels(serum levels of 25(OH)D≥50 nmol/l). In All patients , the AOFAS scores ranged from 44.90 to 94.60, with an average of 63.1±12.8. The VAS scores ranged from 1.0 to 10.0, with an average of 5.6±2.1. The number of affected ankle bones ranged from 2 to 7, with an average of 4.2 ± 1.6. Statistical analysis showed no significant difference comparing vitamin D levels with sex of patients(P＞005). Pearson correlation analysis showed that the serum levels of 25(OH)D was positively correlated with the AOFAS scores(r=0.907, P＜005), and negatively correlated with the VAS scores and the number of affected ankle bones(r=-0.832, r=-0.707, P＜005). There was no significant correlation with age(r=-0.082, P＞005). By multiple linear regression analysis, the correlation between AOFAS scores , VAS scores and the serum levels of 25(OH)D was strongest, the serum levels of 25(OH)D was positively correlated with AOFAS scores, and negatively correlated with VAS scores(standardized regression coefficients=0.593, -1.615, P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Serum levels of 25(OH)D were associated with joint function, pain, and number of affected bones in patients with ankle joint bone marrow edema syndrome（BMES）, and were closely related to AOFAS scores and VAS scores. Therefore, lowlevel vitamin D may be an important factor in the pathogenesis and progression of ankle joint BMES. Vitamin D supplementation will be a new target for the prevention and treatment of ankle joint bone marrow edema syndrome.

Key words: ankle joint, bone marrow edema syndrome, vitamin D