Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the incidence rate, clinical features, risk factors and adverse events during hospitalization and midterm prognosis for postprandial hypotension(PPH) in obesity or overweight patients with coronary heart disease(CHD).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 152 obesity or overweight patients with CHD were selected as the subjects. The blood pressure of patients were monitored by 24 hour ambulatory blood pressure monitor. Subjects were classified into PPH group(n=37) and nonPPH group(NPPH, n=115) according according to PPH diagnostic criteriae. The clinical characteristics of the two groups were compared and the risk factors of PPH, the incidence rate of adverse events and the prognosis of allcause death, cardiovascular and cerebrovascular adverse events were studied.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Among 152 obese or overweight patients with CHD, 37 cases had PPH, the incidence was 24.3%. The proportion of combined with hypertension and taking calcium antagonists in PPH group was higher than that of NPPH group. The incidence rate of PPH at breakfast and dinner was higher than that at lunch. Logistic regression analysis showed that high systolic blood pressure level and oral diuretics were positively correlated with the occurrence of PPH. There was no significant difference in the incidence rate of cardiovascular and cerebrovascular events between the two groups during hospitalization. The 26month followup showed that the incidence of allcause mortality in PPH group was higher than that in NPPH group.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The incidence rate of PPH in obese or overweight patients with CHD was 24.3%. PPH might be likely to occur after breakfast and dinner. High systolic blood pressure and oral diuretics might increase the incidence rate of PPH, and PPH might increase the midterm allcause mortality.

Key words: coronary disease, postprandial hypotension, obesity, overweight