Abstract: ［Abstract］Objective〖HTSS〗To investigate the differential expression and clinical significance of autophagy related protein 16 like protein 1(ATG16L1), galectin9(Gal9), interleukin1β(IL1β) and interleukin33(IL33) in patients of ulcerative colitis(UC) at rest and onset.
〖HTH〗〖WTHZ〗Methods〖HTSS〗One hundred and ten patients with UC were selected as study group. According to the Mayo score,the patients were divided into the resting UC group and the onset UC group, and 40 healthy subjects were selected as the control group. The levels of serum ATG16L1, Gal9, IL1β and IL33 were compared between the three groups, and their correlation with the Mayo score was analyzed. Multivariate Logistic regression analysis of UC onset period was performed.
〖HTH〗〖WTHZ〗Results〖HTSS〗The serum levels of IL1β, IL33, ATG16L1, and Gal9 in the resting UC group and the onset UC group, were significantly higher than those in the control group(P＜0.05), the active UC group was significantly higher than those of the resting UC group(P＜0.05). The serum levels of IL1β, IL33, ATG16L1 and Gal9 were positively correlated with Mayo score(P＜0.05). Multivariate logistic regression analysis showed that IL1β, IL33, ATG16L1, and Gal9 were the influencing factors of UC in the onset.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗The serum levels of IL1β, IL33, Gal9 and ATG16L1 are higher in patients with UC in the onset, which can be used as an independent judgment factor for UC in the onset.

Key words: colitis, ulcerative； autophagy； interleukins, galectins