Abstract: ［Abstract］ Objective〖HTSS〗To investigate the etiological distribution of patients with different degrees of hypercalcemia.
〖HTH〗〖WTHZ〗Methods〖HTSS〗The clinical datas of 58 patients with hypercalcemia were analyzed retrospectively. According to the corrected serum calcium level, the patients were divided into mild hypercalcemia group(22 cases), moderate hypercalcemia group(15 cases)and severe hypercalcemia group(21 cases). The etiology distribution of different degrees of hypercalcemia was observed. The differences of the clinical characteristics between primary hyperparathyroidism(PHPT) and malignancy associated hypercalcemia(MAH) were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗The causes of high calcium levels were found in PHPT, MAH, thyroid function hyperfunction, tertiary hyperparathyroidism. Among the 58 patients with hypercalcemia, PHPT 27 cases(46.55%), MAH 25 cases(43.10%), hyperthyroidism 4 cases(6.90%) with triplex hyperparathyroidism 2 cases(3.45%)   were found. There were more MAH patients in the severe hypercalcemia group than in the mild hypercalcemia group, and the difference was statistically significant(P＜0.05). There was a statistically significant difference in hyperthyroidism amony three groups(P＜0.05), but no statistically significant difference between two groups(P＞0.05). The MAH with the most hypercalcemia was compared with PHPT, and the MAH with lower serum albumin and parathyroid hormone levels than PHPT, higher serum phosphorus and serum creatinine than PHPT, with statistically significant differences(P＜0.05) and no statistically significant differences between MAH and PHPT alkaline phosphatase(P＞0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗Hypercalcemia is most common in patients with PHPT and MAH. MAH is a major cause of severe hypercalcemia. MAH patients had low levels of albumin and parathyroid hormone and high levels of serum creatinine. The detection of biochemical indicators was helpful for clinical diagnosis and treatment.

Key words: hypercalcemia, phyperparathyroidism, parathyroid hormone