Abstract: ［Abstract］Objective To discuss the expression of serum brain derived neurotrophie factor(BDNF) and the application value of BDNF combined with ambulatory electroencephalogram(AEEG) in children with febrile convulsion, providing dependable basis in clinical diagnosis and treatment.
Methods One hundred children with febrile convulsions and 50 healthy children who underwent physical examination at the same time were selected to detect and analyze the serum BDNF level and AEEG of all the selected children.
Results The serum BDNF levels of the simple febrile convulsion group and the complex febrile convulsion group were significantly higher than that of the control group, and the serum BDNF of the complex febrile convulsion group was significantly higher than that of the simple febrile convulsion group(P＜0.05). The incidence of AEEG abnormality in complex febrile convulsion group was significantly higher than that of the simple febrile convulsion group(P＜0.05). But there was no statistical difference in phases and parts distribution of AEEG abnormalities between complex febrile convulsion group and simple febrile convulsion group(P＞0.05). In one year, the incidence of epilepsy in the complex febrile convulsion group was significantly higher than that of the simple febrile convulsion group(P＜0.05). The specificity of BDNF+AEEG in diagnosis of febrile convulsion was significantly higher than that of BDNF and AEEG(P＜0.05). ROC curve analysis showed that the area of BDNF+AEEG was significantly higher than that of BDNF and AEEG(P＜0.05).
Conclusion The combined application of serum BDNF expression level and AEEG has certain value in clinical diagnosis and treatment in febrile convulsion children, and it is worthy of clinical application.

Key words: convulsion, febrile, brain derived neurotrophie factor, ambulatory electroencephalogram