Abstract: ［Abstract］ ObjectiveTo investigate the clinical effects of high frequency oscillatory ventilation(HFOV) combined with normal frequency ventilation(CMV) combined with Sildenafil and colisulla on severe neonatal persistent pulmonary hypertension(PPHN).
〖WTHZ〗MethodsA total of 86 children with severe PPHN were selected and divided into a study group and a control group with 43 cases each according to the random number table method. The control group was treated with sildenafil and CMV treatment. The oxygenation index(OI), oxygen saturation of blood(SpO2), treatment-related indexes, and treatment efficacy were compared between patients of two groups before and 6 h, 12 h, 24 h, 36 h after treatment.
〖WTHZ〗ResultsThe OI of the study group was significantly lower than that of the control group at each time point after treatment. The SpO2 at 12 h, 24 h and 36 h after treatment was significantly higher in the study group than in the control group(P＜0.01). The OI at different time points after treatment was significantly lower than that before treatment. The SpO2 at each time point after treatment was significantly higher than that before treatment. The SpO2 at 36 h after treatment was significantly higher than that before treatment with statistical significance(P＜0.01). The oxygen inhalation time, ventilator use time, hospitalization time, and hospitalization cost of the study group were significantly lower than those of the control group, and the difference was statistically significant(P＜0.01). The total effective rate of the study group was significantly higher than that of the control group, the difference was statistically significant(P＜0.05).
〖WTHZ〗ConclusionSildenafil combined with calsurf and HFOV superimposed CMV in children with heavy negative PPHN can effectively improve pulmonary oxygenation, reduce ventilator use time, oxygen therapy time and improve treatment efficacy.

Key words: hypertension, pulmonary, chest wall oscillation, sildenafil