Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the clinical efficacy of inhaled nitric oxide(NO) combined with high frequency shock ventilation (HFOV) in the treatment of neonatal severe pneumonia. 
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓From January 2012 to December 2016, 54 children with severe neonatal severe pneumonia were enrolled in this study. They were randomly divided into observation group(inhaled NO combined with HFOV treatment) and control group(HFOV treatment), each group of 27 cases. The respiratory function index and blood gas index, and the lung function index after treatment and the time of disappearance of severe pneumoniarelated clinical signs were recorded before and 1 h, 6 h and 24 h after treatment.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The mean airway pressure(MAP), inspired oxygen volume fraction(FiO2), oxygenation index(OI), and a/A interaction between time points and between groups and time points in the two groups were statistically significant(P＜005). There was no significant difference between the groups(P＞005). The differences in arterial oxygen partial pressure(PaO2), carbon dioxide partial pressure(PaCO2), and pH between the two groups were statistically significant(P＜005). There was no significant difference between the groups(P＞005). The forced vital capacity(FVC), forced expiratory volume in one second(FEV1), and peak expiratory flow(PEF)after treatment in the observation group were significantly lower than those in the control group(P＜005). The time of disappearance of clinical signs such as threeindented sign, pulmonary rales, fever, cyanosis, and alar fan was significantly shorter in the observation group than in the control group. The difference was statistically significant(P＜005). 
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Inhaled nitric oxide combined with high frequency shock ventilation in the treatment of neonatal severe pneumonia can significantly improve the children′s respiratory function and blood gas index, and significantly improve the lung function and severe pneumoniarelated clinical signs, has a certain clinical application and research value.

Key words: pneumonia； nitric oxide； chest wall oscillation, infant, newborn