Abstract: ［Abstract］Objective〖HTSS〗To analyze the relationship between serum homocysteine(Hcy) and vascular disease in type 2 diabetes mellitus(T2DM).
 〖WTHZ〗Methods〖HTSS〗Clinical data were collected from 160 participants. Three groups were divided according to type of complication： group I of T2DM with no complications， 51 cases(T2DM group), groupⅡof T2DM with vascular complications(macrovascular disease group), and another 59 normal people without T2DM was randomly as control group. All the detailed information(sex, age, smoking, body mass index(BMI), blood pressure) was recorded in the patient record, and the levels of a series index such as, Hcy, triglyceride(TG), total cholesterol(TC), urea nitrogen(BUN), creatinine(Cr) were measured and compared between the three groups. Then the subjects were divided into the normal Hcy group and the high Hcy group according to the serum Hcy level. The relationship between the serum Hcy level and the incidence of T2DM vascular lesions was analyzed, the influencing factors for the formation of high Hcy and the risk factors related to T2DM vascular lesions were analyzed.
 〖WTHZ〗Results〖HTSS〗The levels of TG,TC, and Hcy in T2DM and macrovascular disease group were significantly higher than in control group(P＜0.01). Hcy in macrovascular disease group were higher than in T2DM group(P＜0.01), and Cr in macrovascular disease group was higher than in T2DM and control group(P＜0.01). With Hcy＞15 μmol/L as the hyperhomocysteinemia(HHcy), the incidence of HHcy in T2DM and macrovascular disease group were significantly higher than in the control group(P＜0.01). The incidence of  high level of fasting plasma glucose（FPG）, glycosylated haemoglobin A1c（GHbA1c）, BUN, TC, TG, Hcy and vascular lesions in HHcy group were significantly higher than in normal Hcy group(P＜0.05). Correlation analysis results showed that Hcy had positive correlation with FPG, GHbA1c, BUN, Cr, TC and TG. Analysis of T2DM related risk factors with Logistic regression analysis showed that TC was an independent risk factor of T2DM with vascular complications.
 〖WTHZ〗Conclusion〖HTSS〗Hcy may be involved in the development of T2DM with vascular complications and is an independent risk factor for vascular disease in T2DM.

Key words: Serum homocysteine, diabetes, type 2, vascular disease