Abstract: ［Abstract］ Objective〖HTSS〗〓To evaluate the effect of clinical intervention on reducing homocysteine (HCY) levels in patients with cardiovascular and cerebrovascular diseases or with high HCY, and to prevent cardiovascular and cerebrovascular diseases.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓CNKI, CBM, Pubmed, OVID and other databases were retrieved by “heart and cerebrovascular disease”, “homocysteine”, “HCY”, “intervention”, “cardiovascular disease” and “homocysteine”. RevMan 5.3 software was used for Metaanalysis.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓A total of 15 randomized controlled trials(45 611 patients) were included. According to the results of Metaanalysis, the difference of cardiovascular and cerebrovascular disease or stroke between the experimental and the control group was statistically significant. For the occurrence of cardiovascular and cerebrovascular disease (0＜x≤24, 24＜x≤48 and 48＜x≤72 months),the pooled OR(95% CI) were 0.390(0.260-0.600), 0.980(0.840-1.160), 0.840(0.730-0.970) in subgroups. For the relapse of stroke, the pooled OR(95% CI) were 0.780(0.620-0.990), 0.320(0.210-0.480) in subgroups were divided according to the treatment plan.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓It has a protective effect on cardiovascular disease if control the intervention time(0＜x≤24 and 48＜x≤72 months) when interfering with the level of HCY. Folic acid, Vitamin B12 and Vitamin B6 have preventive and therapeutic effects on the occurrence and relapse of stroke. It is suggested that the intervention HCY as secondary prevention measures for cardiovascular and cerebrovascular diseases.

Key words: cardiovascular diseases, cerebrovascular disease, Metaanalysis